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IONS Stock Ionis Pharmaceuticals, Inc.

BUY US · NasdaqGS
$43.42 +1.14% Prices as of close 2026-10-27

Late-stage pipeline optionality and substantial consensus upside create a compelling biotechnology setup.

Future value: $83.26 (+91.75%) · 6-12 months

  • ▸Analyst Buy ratings and high consensus price target.
  • ▾Below 50-day MA (-13.57%)
  • ▾Near 52-week low (3% of range)
  • ▸~92% upside to price target

Trend: IONS is trading below the 50-day average (-13.57%), RSI 34 — neutral momentum, with a 3-month return of -21.48%.

Valuation & quality: Ionis Pharmaceuticals, Inc. trades on forward P/E -37.9, PEG 27.33, price-to-book 16.35; fundamentals show net margin -64.7%, return on equity -105.5%, revenue growth -40.7% year on year.

Analyst consensus: 23 analysts have a mean 12-month price target of $84.13 (+93.8% vs the last close; range $58.00 – $105.00), consensus rating “buy”.

Our screen: BUY (score 3) — Late-stage pipeline optionality and substantial consensus upside create a compelling biotechnology setup.

Computed from end-of-day data; not personal advice.

First flagged in our daily picks as BUY on 2026-10-27 at $43.42.

Paper trades from our simulated funds at real end-of-day prices; past results don't predict future returns.

86.3 42.4 FebMarAprMayJunJulAugSepOct
Daily close, 2026-02-09 → 2026-10-26 (USD). Range 42.4 – 86.3.
Mar 26Apr 26May 26Jun 26Jul 26Aug 26Sep 26Oct 26
-7.50%-0.40%+2.30%+3.60%-34.70%+16.60%-26.00%-2.80%
Market cap
$7.22B
P/E (ttm)
-37.9
Forward P/E
-37.9
EPS (ttm)
$-3.45
Price / book
16.35
PEG
27.33
Beta
0.38
Net margin
-64.7%
ROE
-105.5%
Revenue growth
-40.7%
Revenue (ttm)
$874.1M
Free cash flow
$-346,764,640
Debt / equity
498%
52-wk range
$42.08 – $86.74
Volume
3,197,333
Avg volume (3m)
3,196,152
Mean target
$84.13
Low
$58.00
High
$105.00
Analysts
23
Consensus
BUY
RSI (14)
34.4
vs 50-day MA
-13.57%
1-mo return
-2.43%
3-mo return
-21.48%
Volume z-score
0.55

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States.

Sector: Healthcare · Industry: Biotechnology · United States · 1,480 employees · Website

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Market data from end-of-day feeds; AI-generated research for educational purposes only — not investment advice.